Research

Ben McFarland runs a research group in protein design at Seattle Pacific University. Current areas of interest include analyzing the NKG2D-MICA immunoreceptor-protein interaction, redesigning that interaction as a scaffold for tunable binding, bioinformatics of amino acid metabolism, and bringing research into the undergraduate teaching lab.

Ben’s Google Scholar page

Ben’s ResearchGate page

Key recent publications:

“Mutations Designed to Destabilize the Receptor-Bound Conformation Increase MICA-NKG2D Association Rate and Affinity” in the Journal of Biological Chemistry

“Preparative Protein Production from Inclusion Bodies and Crystallization: A Seven-Week Biochemistry Sequence” in the Journal of Chemical Education

“Combining different design strategies for rational affinity maturation of the MICA-NKG2D interface” in Protein Science